Hyaluronic acid - abbreviated HA - Hyaluronan

Hyaluronic acid (/ˌhaɪ.əljʊəˈrɒnɪk/;[2][3] abbreviated HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans as it is non-sulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large: human synovial HA averages about 7 million Da per molecule, or about 20,000 disaccharide monomers,[4] while other sources mention 3–4 million Da.[5]

As one of the chief components of the extracellular matrix, it contributes significantly to cell proliferation and migration, and is involved in the progression of many malignant tumors.[6][7] The average 70 kg (150 lb) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (i.e., degraded and synthesized) per day.[8] Hyaluronic acid is also a component of the group A streptococcal extracellular capsule,[9] and is believed to play a role in virulence

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